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| Description Synuclein, a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282), participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128). Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Defects in α-synuclein have been implicated in the pathogenesis of Parkinson disease. Alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. | ||
| Species Reactivity | Human, Mouse | |
| Application | WB, ELISA, IP | |
| Isotype | Mouse IgG1 Kappa | |
| Antibody Type | Monoclonal antibody | |
| Immunogen | Human recombinant alpha synuclein protein (NM_000345.4) produced in E.coli. | |
| Form | Liquid | |
| Formulation | Phosphate-buffered solution; no preservatives or carrier proteins. | |
| Preparation | The antibody was purified by affnity chromatography. | |
| Purity | SDS-PAGE > 95% | |
| Concentration | 0.5 mg/mL | |
| Endotoxin | 0-1EU/mg | |
| Storage Conditions | Store at 2°C to 8°C short term (1-2 weeks). Store at -80°C long term (36 months). Avoid thaw and freeze cycle. | |
| Shipping Conditions | Ambient (domestic); Wet ice (international) | |
| Limitations | Our products are to be used for Research Use Only. | |
| Data Sheet | ▼ Safety Data Sheet (SDS) ▼ Data Sheet ▼ CoA | |
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